Since it began, the COVID-19 pandemic has exacerbated social inequalities in health, defined by the World Health Organization (WHO) as systemic differences in health that arise from social determinants, putting the most vulnerable populations at risk of becoming more fragile and impoverished. In the face of this, the non-profit sector can be a key player and a pillar of resilience for these populations, thanks to its community and social approach. In this article, we propose to examine the contribution of this approach in times of health crisis as an effective lever for action for protecting vulnerable populations from the effects of the pandemic, based on a case study: the Ikambere association, located in Saint-Denis in France’s Île-de-France region. After reviewing the theoretical and conceptual foundations of the community-based approach to health, this article analyzes how the support offered by Ikambere to vulnerable women has helped them increase their knowledge and resilience in order to recover from the crisis. It concludes by stressing the importance of better integrating the community approach as an integral part of the public health strategy in order to combat social inequalities in health in a more sustainable and effective manner.