People living with HIV face unequal treatments linked to their HIV status and other discriminations including racism and homophobia. Using data from the Vespa2 survey, this article analyses the way by which discriminations play out among HIV patients, looking into different social contexts: workplace, health services and family. High levels of discrimination usually reflect racial and socio-economic hierarchies. This article argues that they also relate to gender relations. It shows that discrimination seems to be a bigger issue for women, gay men and male drug users suffering from HIV, mainly because they are seen as deviating from gendered prescribed roles. This experience of discrimination unveils the unequal social relations expressed within the family and calls for an extension of the study of discrimination to the private sphere.